The von Willebrand factor stamps plasmatic extracellular vesicles from glioblastoma patients.

ABSTRACT: Glioblastoma is a devastating tumor of the central nervous system characterized by a poor survival and an extremely dark prognosis, making its diagnosis, treatment and monitoring highly challenging. Numerous studies have highlighted extracellular vesicles (EVs) as key players of tumor growth, invasiveness and resistance, as they carry and disseminate oncogenic material in the local tumor microenvironment and at distance. However, whether their quality and quantity reflect individual health status and changes in homeostasis is still not fully elucidated. Here, we separated EVs from plasma collected at different time points alongside with the clinical management of GBM patients. Our findings confirm that plasmatic EVs could be separated and characterized with standardized protocols, thereby

SUBMITTER: Sabbagh Q 

PROVIDER: S-EPMC8611030 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature