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ABSTRACT: Objectives
We evaluated antibody response to the BNT162B2 vaccine among healthcare workers (HCWs) to identify factors associated with decreased immunogenicity.Methods
This prospective cohort study included consenting HCWs who completed a questionnaire regarding background illnesses, medications, and post vaccination allergic reactions or rash. All HCWs were tested for anti-spike antibodies (LIAISON SARS-CoV-2 S1/S2 IgG assay) one and three months after second vaccine dose. A multivariate mixed linear model was adjusted to participant's data and fit to predict antibody levels after second BNT162B2 vaccine dose, based on antibody levels at 1 month and the slope between 3 and 1 month. Multivariate analyses identified factors associated with lower antibody levels.Results
A total of 1,506 HCWs were tested for SARS-CoV-2 antibodies. Older age was associated with lower mean antibody levels (-1.22 AU/ml, p <0.001, 95% CI -1.43 - -1.01). In addition, male (-22.16AU/ml, p <0.001, 95% CI -27.93 - -16.39), underlying condition (-10.86AU/ml, p= 0.007, 95% CI -18.81 - -2.91) and immunosuppressive treatment (-28.57AU/ml, p = 0.002, 95% CI -46.85 - -10.29) were associated with significantly lower mean antibody levels. Allergic reactions after vaccine administration or peri vaccination GCS treatment were not correlated with antibody levels.Conclusions
Most HCWs had measurable antibodies at 3 months. Risk factors for lower antibody levels were older age, male sex, underlying condition, and immunosuppressive treatment. These factors may be considered when planning booster doses during vaccine shortage.
SUBMITTER: Shachor-Meyouhas Y
PROVIDER: S-EPMC8611821 | biostudies-literature |
REPOSITORIES: biostudies-literature