Epione application: An integrated web‑toolkit of clinical genomics and personalized medicine in systemic lupus erythematosus.

ABSTRACT: Genome wide association studies (GWAS) have identified autoimmune disease‑associated loci, a number of which are involved in numerous disease‑associated pathways. However, much of the underlying genetic and pathophysiological mechanisms remain to be elucidated. Systemic lupus erythematosus (SLE) is a chronic, highly heterogeneous autoimmune disease, characterized by differences in autoantibody profile, serum cytokines and a multi‑system involvement. This study presents the Epione application, an integrated bioinformatics web‑toolkit, designed to assist medical experts and researchers in more accurately diagnosing SLE. The application aims to identify the most credible gene variants and single nucleotide polymorphisms (SNPs) associated with SLE susceptibility, by using patient's genomic dat

SUBMITTER: Papageorgiou L 

PROVIDER: S-EPMC8612305 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature