Self-adaptive cardiac optogenetics device based on negative stretching-resistive strain sensor.

ABSTRACT: Precision medicine calls for high demand of continuous, closed-loop physiological monitoring and accurate control, especially for cardiovascular diseases. Cardiac optogenetics is promising for its superiority of cell selectivity and high time-space accuracy, but the efficacy of optogenetics relative to the input of light stimulus is detected and controlled separately by discrete instruments in vitro, which suffers from time retardation, energy consumption, and poor portability. Thus, a highly integrated system based on implantable sensors combining closed-loop self-monitoring with simultaneous treatment is highly desired. Here, we report a self-adaptive cardiac optogenetics system based on an original negative stretching-resistive strain sensor array for closed-loop heart rate recording an

SUBMITTER: Hong W 

PROVIDER: S-EPMC8612680 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature