Dendritic synapse geometry optimizes binaural computation in a sound localization circuit.
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ABSTRACT:
SUBMITTER: Yamada R
PROVIDER: S-EPMC8612683 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Dendritic synapse geometry optimizes binaural computation in a sound localization circuit.
Science advances 20211124 48
Clustering of synapses allows neurons to overcome attenuation of electrical signals at dendrites. However, we show in avian binaural coincidence detectors computing interaural time difference for sound localization that clustering of synapses rather promotes the dendritic attenuation but augments the intensity tolerance of the binaural computations. Using glutamate uncaging, we found in the neurons that synapses were clustered at distal dendritic branches. Modeling revealed that this strengthene ...[more]
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