Liver injury changes the biological characters of serum small extracellular vesicles and reprograms hepatic macrophages in mice.

ABSTRACT:

Background

Serum small extracellular vesicles (sEVs) and their small RNA (sRNA) cargoes could be promising biomarkers for the diagnosis of liver injury. However, the dynamic changes in serum sEVs and their sRNA components during liver injury have not been well characterized. Given that hepatic macrophages can quickly clear intravenously injected sEVs, the effect of liver injury-related serum sEVs on hepatic macrophages deserves to be explored.

Aim

To identify the characteristics of serum sEVs and the sRNAs during liver injury and explore their effects on hepatic macrophages.

Methods

To identify serum sEV biomarkers for liver injury, we established a CCL₄-induced mouse liver injury model in C57BL/6 mice to simulate acute liver injury (ALI), chronic liver inj

SUBMITTER: Lv XF 

PROVIDER: S-EPMC8613741 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature