Genome-wide map of N⁶-methyladenosine circular RNAs identified in mice model of severe acute pancreatitis.

ABSTRACT:

Background

Severe acute pancreatitis (SAP) is a deadly inflammatory disease with complex pathogenesis and lack of effective therapeutic options. N⁶-methyladenosine (m⁶A) modification of circRNAs plays important roles in physiological and pathological processes. However, the roles of m⁶A circRNA in the pathological process of SAP remains unknown.

Aim

To identify transcriptome-wide map of m⁶A circRNAs and to determine their biological significance and potential mechanisms in SAP.

Methods

The SAP in C57BL/6 mice was induced using 4% sodium taurocholate salt. The transcriptome-wide map of m⁶A circRNAs was identified by m⁶A-modified RNA immunoprecipitation sequencing. The biological significance of circRNAs

SUBMITTER: Wu J 

PROVIDER: S-EPMC8613746 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature