Ontology highlight
ABSTRACT:
SUBMITTER: Herrero-Cervera A
PROVIDER: S-EPMC8615201 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Herrero-Cervera Andrea A Espinós-Estévez Carla C Martín-Vañó Susana S Taberner-Cortés Alida A Aguilar-Ballester María M Vinué Ángela Á Piqueras Laura L Martínez-Hervás Sergio S González-Navarro Herminia H
Biomedicines 20211022 11
Abdominal aortic aneurysm (AAA), is a complex disorder characterized by vascular vessel wall remodeling. LIGHT (TNFSF14) is a proinflammatory cytokine associated with vascular disease. In the present study, the impact of genetic inactivation of <i>Light</i> was investigated in dissecting AAA induced by angiotensin II (AngII) in the Apolipoprotein E-deficient (<i>Apoe</i><sup>-/-</sup>) mice. Studies in aortic human (ah) vascular smooth muscle cells (VSMC) to study potential translation to human ...[more]