Diagnostic Accuracy of Liquid Biopsy in Endometrial Cancer.

ABSTRACT: Liquid biopsy is a minimally invasive collection of a patient body fluid sample. In oncology, they offer several advantages compared to traditional tissue biopsies. However, the potential of this method in endometrial cancer (EC) remains poorly explored. We studied the utility of tumor educated platelets (TEPs) and circulating tumor DNA (ctDNA) for preoperative EC diagnosis, including histology determination. TEPs from 295 subjects (53 EC patients, 38 patients with benign gynecologic conditions, and 204 healthy women) were RNA-sequenced. DNA sequencing data were obtained for 519 primary tumor tissues and 16 plasma samples. Artificial intelligence was applied to sample classification. Platelet-dedicated classifier yielded AUC of 97.5% in the test set when discriminating between healthy subj

SUBMITTER: Lukasiewicz M 

PROVIDER: S-EPMC8616122 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature