Ontology highlight
ABSTRACT:
SUBMITTER: Tan GW
PROVIDER: S-EPMC8616181 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Tan Geok Wee GW Jiang Peijia P Nolte Ilja M IM Kushekhar Kushi K Veenstra Rianne N RN Hepkema Bouke G BG Jarrett Ruth F RF van den Berg Anke A Diepstra Arjan A
Cancers 20211120 22
Several human leukocyte antigen (HLA) alleles are strongly associated with susceptibility to classic Hodgkin lymphoma (cHL), also in subgroups stratified for presence of the Epstein-Barr virus (EBV). We tested the hypothesis that the pressure on cHL tumour cells to lose HLA expression is associated with HLA susceptibility alleles. A meta-analysis was carried out to identify consistent protective and risk HLA alleles in a combined cohort of 839 cHL patients from the Netherlands and the United Kin ...[more]