NAD Modulates DNA Methylation and Cell Differentiation.
Ontology highlight
ABSTRACT:
SUBMITTER: Ummarino S
PROVIDER: S-EPMC8616462 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
NAD Modulates DNA Methylation and Cell Differentiation.
Ummarino Simone S Hausman Clinton C Gaggi Giulia G Rinaldi Lucrezia L Bassal Mahmoud A MA Zhang Yanzhou Y Seelam Andy Joe AJ Kobayashi Ikei S IS Borchiellini Marta M Ebralidze Alexander K AK Ghinassi Barbara B Trinh Bon Q BQ Kobayashi Susumu S SS Di Ruscio Annalisa A
Cells 20211102 11
Nutritional intake impacts the human epigenome by directing epigenetic pathways in normal cell development via as yet unknown molecular mechanisms. Consequently, imbalance in the nutritional intake is able to dysregulate the epigenetic profile and drive cells towards malignant transformation. Here we present a novel epigenetic effect of the essential nutrient, NAD. We demonstrate that impairment of DNMT1 enzymatic activity by NAD-promoted ADP-ribosylation leads to demethylation and transcription ...[more]
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