Dataset Information

Cardiovascular ¹⁸F-fluoride positron emission tomography-magnetic resonance imaging: A comparison study.

ABSTRACT:

Background

¹⁸F-Fluoride uptake denotes calcification activity in aortic stenosis and atherosclerosis. While PET/MR has several advantages over PET/CT, attenuation correction of PET/MR data is challenging, limiting cardiovascular application. We compared PET/MR and PET/CT assessments of ¹⁸F-fluoride uptake in the aortic valve and coronary arteries.

Methods and results

18 patients with aortic stenosis or recent myocardial infarction underwent ¹⁸F-fluoride PET/CT followed immediately by PET/MR. Valve and coronary ¹⁸F-fluoride uptake were evaluated independently. Both standard (Dixon) and novel radial GRE) MR attenuation correction (AC) maps were validated against PET/CT with results expressed as tissue-to-background ratios (TBRs). Visually, aortic valve ¹⁸F-fluoride uptake was similar on PET/CT and PET/MR. TBR_MAX values were comparable with radial GRE AC (PET/CT 1.55±0.33 vs. PET/MR 1.58 ± 0.34, P = 0.66; 95% limits of agreement - 27% to + 25%) but performed less well with Dixon AC (1.38 ± 0.44, P = 0.06; bias (-)14%; 95% limits of agreement - 25% to + 53%). In native coronaries, ¹⁸F-fluoride uptake was similar on PET/MR to PET/CT regardless of AC approach. PET/MR identified 28/29 plaques identified on PET/CT; however, stents caused artifact on PET/MR making assessment of ¹⁸F-fluoride uptake challenging.

Conclusion

Cardiovascular PET/MR demonstrates good visual and quantitative agreement with PET/CT. However, PET/MR is hampered by stent-related artifacts currently limiting clinical application.

SUBMITTER: Andrews JPM

PROVIDER: S-EPMC8616877 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Cardiovascular <sup>18</sup>F-fluoride positron emission tomography-magnetic resonance imaging: A comparison study.

Andrews Jack P M JPM MacNaught Gillian G Moss Alastair J AJ Doris Mhairi K MK Pawade Tania T Adamson Philip D PD van Beek Edwin J R EJR Lucatelli Christophe C Lassen Martin L ML Robson Philip M PM Fayad Zahi A ZA Kwiecinski Jacek J Slomka Piotr J PJ Berman Daniel S DS Newby David E DE Dweck Marc R MR

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20191202 5

<h4>Background</h4><sup>18</sup>F-Fluoride uptake denotes calcification activity in aortic stenosis and atherosclerosis. While PET/MR has several advantages over PET/CT, attenuation correction of PET/MR data is challenging, limiting cardiovascular application. We compared PET/MR and PET/CT assessments of <sup>18</sup>F-fluoride uptake in the aortic valve and coronary arteries.<h4>Methods and results</h4>18 patients with aortic stenosis or recent myocardial infarction underwent <sup>18</sup>F-flu ...[more]

PMID: 31792913

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Dataset Information

Cardiovascular ¹⁸F-fluoride positron emission tomography-magnetic resonance imaging: A comparison study.

Background

Methods and results

Conclusion

Publications

Cardiovascular <sup>18</sup>F-fluoride positron emission tomography-magnetic resonance imaging: A comparison study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Cardiovascular 18F-fluoride positron emission tomography-magnetic resonance imaging: A comparison study.

Background

Methods and results

Conclusion

Publications

Cardiovascular <sup>18</sup>F-fluoride positron emission tomography-magnetic resonance imaging: A comparison study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Cardiovascular ¹⁸F-fluoride positron emission tomography-magnetic resonance imaging: A comparison study.