Unknown

Dataset Information

0

Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men.


ABSTRACT: Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations.

SUBMITTER: Sahlin KB 

PROVIDER: S-EPMC8619397 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Short-Term Effect of Induced Alterations in Testosterone Levels on Fasting Plasma Amino Acid Levels in Healthy Young Men.

Sahlin K Barbara KB   Pla Indira I   de Siqueira Guedes Jéssica J   Pawłowski Krzysztof K   Appelqvist Roger R   Marko-Varga György G   Domont Gilberto Barbosa GB   César Sousa Nogueira Fábio F   Giwercman Aleksander A   Sanchez Aniel A   Malm Johan J  

Life (Basel, Switzerland) 20211122 11


Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacological  ...[more]

Similar Datasets

| S-EPMC5260087 | biostudies-literature
| S-EPMC9508133 | biostudies-literature
| S-EPMC4320164 | biostudies-literature
| S-EPMC6636393 | biostudies-literature
| S-EPMC11825603 | biostudies-literature
| S-EPMC7468950 | biostudies-literature
2025-06-04 | PXD057146 | Pride
| S-EPMC9154271 | biostudies-literature
| S-EPMC10409833 | biostudies-literature
| S-EPMC7261685 | biostudies-literature