Unknown

Dataset Information

0

Urinary SARS-CoV-2 RNA Is an Indicator for the Progression and Prognosis of COVID-19.


ABSTRACT:

Background

We aimed to analyze clinical characteristics and find potential factors to predict poor prognosis in patients with coronavirus disease 2019 (COVID-19).

Methods

We analyzed the clinical characteristics and laboratory tests of COVID-19 patients and detected SARS-CoV-2 RNA in urine sediments collected from 53 COVID-19 patients enrolled in Renmin Hospital of Wuhan University from 31 January 2020 to 18 February 2020 with qRT-PCR analysis. Then, we classified those patients based on clinical conditions (severe or non-severe syndrome) and urinary SARS-CoV-2 RNA (URNA- or URNA+).

Results

We found that COVID-19 patients with severe syndrome (severe patients) showed significantly higher positive rate (11 of 23, 47.8%) of urinary SARS-CoV-2 RNA than non-severe patients (4 of 30, 13.3%, p = 0.006). URNA+ patients or severe URNA+ subgroup exhibited higher prevalence of inflammation and immune discord, cardiovascular diseases, liver damage and renal dysfunction, and higher risk of death than URNA- patients. To understand the potential mechanisms underlying the viral urine shedding, we performed renal histopathological analysis on postmortems of patients with COVID-19 and found severe renal vascular endothelium lesion characterized by an increase of the expression of thrombomodulin and von Willebrand factor, markers to assess the endothelium dysfunction. We proposed a theoretical and mathematic model to depict the potential factors that determine the urine shedding of SARS-CoV-2.

Conclusions

This study indicated that urinary SARS-CoV-2 RNA detected in urine specimens can be used to predict the progression and prognosis of COVID-19 severity.

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8619898 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7899468 | biostudies-literature
| S-SCDT-EMM-2022-15904 | biostudies-other
| S-EPMC7711740 | biostudies-literature
| S-SCDT-10_15252-EMBR_202256055 | biostudies-other
2021-06-19 | E-MTAB-10442 | biostudies-arrayexpress
| S-EPMC7857607 | biostudies-literature
2021-04-09 | GSE171668 | GEO
2022-02-05 | E-MTAB-10740 | biostudies-arrayexpress