Unknown

Dataset Information

0

Unified representation of high- and low-resolution spectra to facilitate application of mass spectrometric techniques in clinical practice.


ABSTRACT: The majority of research in the biomedical sciences is carried out with the highest resolution accessible to the scientist, but, in the clinic, cost constraints necessitate the use of low-resolution devices. Here, we compare high- and low-resolution direct mass spectrometry profiling data and propose a simple pre-processing technique that makes high-resolution data suitable for the development of classification and regression techniques applicable to low-resolution data, while retaining high accuracy of analysis. This work demonstrates an approach to de-noising spectra to make the same representation for both high- and low-resolution spectra. This approach uses noise threshold detection based on the Tversky index, which compares spectra with different resolutions, and minimizes the percentage of resolution-specific peaks. The presented method provides an avenue for the development of analytical algorithms using high-resolution mass spectrometry data, while applying these algorithms in the clinic using low-resolution mass spectrometers.

SUBMITTER: Zhvansky ES 

PROVIDER: S-EPMC8620137 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7995644 | biostudies-literature
| S-EPMC7914584 | biostudies-literature
| S-EPMC4481842 | biostudies-literature
| S-EPMC6458998 | biostudies-literature
| S-EPMC10133483 | biostudies-literature
| S-EPMC4219163 | biostudies-other
| S-EPMC3334617 | biostudies-literature
| S-EPMC4507422 | biostudies-literature
| S-EPMC3334416 | biostudies-literature
| S-EPMC3586292 | biostudies-literature