Unknown

Dataset Information

0

Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice.


ABSTRACT: The sex chromosomes play central roles in determining the sex of almost all of the multicellular organisms. It is well known that meiosis in mammalian spermatogenesis produces ~50% Y- and ~50% X-chromosome-bearing sperm, a 1:1 ratio. Here we first reveal that the X-chromosome-encoded miRNAs show lower expression levels in the left testis than in the right testis in healthy mice using bioinformatics modeling of miRNA-sequencing data, suggesting that the Y:X ratio could be unbalanced between the left testis and the right testis. We further reveal that the Y:X ratio is significantly elevated in the left testis but balanced in the right testis using flow cytometry. This study represents the first time the biased Y:X ratio in the left testis but not in the right testis is revealed.

SUBMITTER: Hu C 

PROVIDER: S-EPMC8621333 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7347495 | biostudies-literature
| S-EPMC8464243 | biostudies-literature
| S-EPMC7336842 | biostudies-literature
| S-EPMC6839398 | biostudies-literature
2016-08-09 | E-GEOD-79768 | biostudies-arrayexpress
| S-EPMC9332913 | biostudies-literature
| S-EPMC7661448 | biostudies-literature
| S-EPMC5567907 | biostudies-literature
| S-EPMC4413009 | biostudies-literature
| S-EPMC3562789 | biostudies-literature