Ontology highlight
ABSTRACT:
SUBMITTER: Chung H
PROVIDER: S-EPMC8621681 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Chung Hyunmin H Jung Haiyoung H Noh Ji-Yoon JY
International journal of molecular sciences 20211109 22
Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient's autologous T cells, combined with engineered T cell receptors, has shown remarkable results, with five US Food and Drug Administration (FDA) approvals to date. CAR-T cells have been very effective in hematologic malignancies, such as diffuse large B cell lymphoma (DL ...[more]