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The contribution of low contrast-preferring neurons to information representation in the primary visual cortex after learning.

ABSTRACT: Animals exhibit improved perception of lower-contrast visual objects after training. We explored this neuronal mechanism using multiple single-unit recordings from deep layers of the primary visual cortex (V1) of trained rats during orientation discrimination. We found that the firing rates of a subset of neurons increased by reducing luminance contrast, being at least above basal activities at low contrast. These low contrast–preferring neurons were rare during passive viewing without training or anesthesia after training. They fired more frequently in correct-choice than incorrect-choice trials. At single-neuron and population levels, they efficiently represented low-contrast orientations. Following training, in addition to generally enhanced excitation, the phase synchronization of spikes to beta oscillations at high contrast was stronger in putative inhibitory than excitatory neurons. The change in excitation-inhibition balance might contribute to low-contrast preference. Thus, low-contrast preference in V1 activity is strengthened in an experience-dependent manner, which may contribute to low-contrast visual discrimination.

SUBMITTER: Kimura R

PROVIDER: S-EPMC8626071 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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The contribution of low contrast-preferring neurons to information representation in the primary visual cortex after learning.

Kimura Rie R Yoshimura Yumiko Y

Science advances 20211126 48

Animals exhibit improved perception of lower-contrast visual objects after training. We explored this neuronal mechanism using multiple single-unit recordings from deep layers of the primary visual cortex (V1) of trained rats during orientation discrimination. We found that the firing rates of a subset of neurons increased by reducing luminance contrast, being at least above basal activities at low contrast. These low contrast–preferring neurons were rare during passive viewing without training ...[more]

PMID: 34826242

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Project description:In the cat primary visual cortex, it is accepted that neurons optimally responding to similar stimulus orientations are clustered in a column extending from the superficial to deep layers. The cerebral cortex is, however, folded inside a skull, which makes gyri and fundi. The primary visual area of cats, area 17, is located on the fold of the cortex called the lateral gyrus. These facts raise the question of how to reconcile the tangential arrangement of the orientation columns with the curvature of the gyrus. In the present study, we show a possible configuration of feature representation in the visual cortex using a three-dimensional (3D) self-organization model. We took into account preferred orientation, preferred direction, ocular dominance and retinotopy, assuming isotropic interaction. We performed computer simulation only in the middle layer at the beginning and expanded the range of simulation gradually to other layers, which was found to be a unique method in the present model for obtaining orientation columns spanning all the layers in the flat cortex. Vertical columns of preferred orientations were found in the flat parts of the model cortex. On the other hand, in the curved parts, preferred orientations were represented in wedge-like columns rather than straight columns, and preferred directions were frequently reversed in the deeper layers. Singularities associated with orientation representation appeared as warped lines in the 3D model cortex. Direction reversal appeared on the sheets that were delimited by orientation-singularity lines. These structures emerged from the balance between periodic arrangements of preferred orientations and vertical alignment of the same orientations. Our theoretical predictions about orientation representation were confirmed by multi-slice, high-resolution functional MRI in the cat visual cortex. We obtained a close agreement between theoretical predictions and experimental observations. The present study throws a doubt about the conventional columnar view of orientation representation, although more experimental data are needed.

Dataset Information

The contribution of low contrast-preferring neurons to information representation in the primary visual cortex after learning.

Publications

The contribution of low contrast-preferring neurons to information representation in the primary visual cortex after learning.

Similar Datasets

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