Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer is a common malignancy occurring in the digestive system and ranks second in cancer mortality worldwide. In colorectal cancer, hydrogen sulfide (H₂S) is selectively upregulated, resulting in the further exacerbation of the disease. Therefore, the clearance of H₂S and the regulation of the enzymes on the H₂S pathways are of great significance for colorectal cancer therapy.

Methods

Here, we investigated the H₂S content in various clinical tumor tissues from patients and confirmed that overproduced concentration of H₂S in colorectal cancer. Accordingly, we developed an H₂S-responsive nanoplatform based on zinc oxide coated virus-like silica nanoparticles (VZnO) for the therapy of colo

SUBMITTER: Pan X 

PROVIDER: S-EPMC8626909 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature