Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC8628514 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Li Shasha S McCraw Alex J AJ Gardner Richard A RA Spencer Daniel I R DIR Karagiannis Sophia N SN Wagner Gerd K GK
Antibodies (Basel, Switzerland) 20211104 4
Monoclonal antibodies (mAbs) are one of the cornerstones of modern medicine, across an increasing range of therapeutic areas. All therapeutic mAbs are glycoproteins, i.e., their polypeptide chain is decorated with glycans, oligosaccharides of extraordinary structural diversity. The presence, absence, and composition of these glycans can have a profound effect on the pharmacodynamic and pharmacokinetic profile of individual mAbs. Approaches for the glycoengineering of therapeutic mAbs-the manipul ...[more]