Dataset Information

Bandgap Modulation of Cs₂AgInX₆ (X = Cl and Br) Double Perovskite Nano- and Microcrystals via Cu²⁺ Doping.

ABSTRACT: Recently, the double perovskite Cs₂AgInCl₆, which has high stability and low toxicity, has been proposed as a potential alternative to Pb-based perovskites. However, the calculated parity-allowed transition bandgap of Cs₂AgInCl₆ is 4.25 eV; this wide bandgap makes it difficult to use as an efficient solar absorber. In this study, we explored the effect of Cu doping on the optical properties of Cs₂AgInCl₆ double perovskite nano- and microcrystals (MCs), particularly in its changes of absorption profile from the ultraviolet (UV) to near-infrared (NIR) region. Undoped Cs₂AgInCl₆ showed the expected wide bandgap absorbance, but the Cu-doped sample showed a new sharp absorption peak at 419 nm and broad absorption bands near 930 nm, indicating bandgap reduction. Electron paramagnetic resonance (EPR) spectroscopy demonstrated that this bandgap reduction effect was due to the Cu doping in the double perovskite and confirmed that the Cu²⁺ paramagnetic centers were located on the surface of the nanocrystals (NCs) and at the center of the perovskite octahedrons (g_∥ > g_⊥ > g_e). Finally, we synthesized Cu-doped Cs₂AgInCl₆ MCs and observed results similar to those of the NCs, showing that the application range could be expanded to multidimensions.

SUBMITTER: Kim K

PROVIDER: S-EPMC8628852 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:BackgroundDiacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tumor location dependent. Here, we first analyzed uptake of Cu-ATSM and its less lipophilic counterpart Cu-Cl2 in the tumor over time in an orthotopic glioblastoma model. An in vitro study was also conducted to investigate the hypoxia-dependent copper uptake in tumor cells. We then further performed a comprehensive ex vivo study to compare 64Cu uptake to hypoxic markers, specific cellular reactions, and also transporter expression.MethodsμPET was performed 14 days (18F-FMISO), 15 days (64Cu-ATSM and 64Cu-Cl2), and 16 days (64Cu-ATSM and 64Cu-Cl2) after C6 cell inoculation. Thereafter, the brains were withdrawn for further autoradiography and immunohistochemistry. C6 cells were also grown in hypoxic workstation to analyze cellular uptake of Cu complexes in different oxygen levels.ResultsIn vivo results showed that Cu-ASTM and Cu-Cl2 accumulated in hypoxic areas of the tumors. Cu-ATSM also stained, to a lesser extent, non-hypoxic regions, such as regions of astrogliosis, with high expression of copper transporters and in particular DMT-1 and CTR1, and also characterized by the expression of elevated astrogliosis. In vitro results show that 64Cu-ATSM showed an increase in the uptake only in severe hypoxia at 0.5 and 0.2% of oxygen while for 64Cu-Cl2, the cell retention was significantly increased at 5% and 1% of oxygen with no significant rise at lower oxygen percentages.ConclusionIn the present study, we show that Cu-complexes undoubtedly accumulate in hypoxic areas of the tumors. This uptake may be the reflection of a direct dependency to a redox metabolism and also a reflection of hypoxic-induced overexpression of transporters. We also show that Cu-ATSM also stained non-hypoxic regions such as astrogliosis.

Dataset Information

Bandgap Modulation of Cs₂AgInX₆ (X = Cl and Br) Double Perovskite Nano- and Microcrystals via Cu²⁺ Doping.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Bandgap Modulation of Cs2AgInX6 (X = Cl and Br) Double Perovskite Nano- and Microcrystals via Cu2+ Doping.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Bandgap Modulation of Cs₂AgInX₆ (X = Cl and Br) Double Perovskite Nano- and Microcrystals via Cu²⁺ Doping.