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Fear, Affective Semiosis, and Management of the Pandemic Crisis: Covid-19 as Semiotic Vaccine?

ABSTRACT: The COVID-19 pandemic represents an extraordinary challenge to clinicians, health care institutions and policymakers. The paper outlines a psychoanalytically grounded semiotic-cultural psychological interpretation of such a scenario. First, we underline how the actual emotional reaction (mainly of fear) of our society is a marker of how the mind functions in conditions of affective activation related to heightened uncertainty: it produces global, homogenizing and generalizing embodied interpretations of reality, at the cost of more fine-grained and differentiated analytical thought. Such a process, called affective semiosis, represents an adaptive response to the emergency in the short-term. Second, we argue that this adaptive value provided by affective semiosis will be reduced when we have to deal with the process of managing the transition to the post-crisis and the governance of the medium and longterm impact of the crisis. Third, we suggest that, in order to manage the pandemic crisis on a longer temporal frame, affective semiosis has to be integrated with less generalized and more domain-specific ways of interpreting reality. To this end, semiotic capital (i.e., culturally-mediated symbolic resources) should be promoted in order to enable people to interiorize the supra-individual and collective dimension of life. Accordingly, COVID-19 is proposed as a semiotic vaccine, a disruption in our everyday life routines which has the potential of opening the way to a semiotic reappropriation of the collective dimensions of our experience.

SUBMITTER: Venuleo C

PROVIDER: S-EPMC8629038 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:In the last two years, the coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a scientific and social challenge worldwide. Vaccines have been the most effective intervention for reducing virus transmission and disease severity. However, virus genetic variants are still circulating among vaccinated individuals with different symptomatology disease cases. Understanding the protective or disease associated mechanisms in vaccinated individuals is relevant to advance in vaccine development and implementation. To address this objective, serum protein profiles were characterized by quantitative proteomics and data analysis algorithms in four cohorts of vaccinated individuals uninfected and SARS-CoV-2 infected with asymptomatic, nonsevere and severe disease symptomatology. The results showed that immunoglobulins were the most overrepresented proteins in infected cohorts when compared to PCR-negative individuals. The immunoglobulin profile varied between different infected cohorts and correlated with protective or disease associated capacity. Overrepresented immunoglobulins in PCR-positive individuals correlated with protective response against SARS-CoV-2, other viruses, and thrombosis in asymptomatic cases. In nonsevere cases, correlates of protection against SARS-CoV-2 and HBV together with risk of myasthenia gravis and allergy and autoantibodies were observed. Patients with severe symptoms presented risk for allergy, chronic idiopathic thrombocytopenic purpura, and autoantibodies. The analysis of underrepresented immunoglobulins in PCR-positive compared to PCR-negative individuals identified vaccine-induced protective epitopes in various coronavirus proteins including the Spike receptor-binding domain RBD. Non-immunoglobulin proteins were associated with COVID-19 symptoms and biological processes. These results evidence host-associated differences in response to vaccination and the possibility of improving vaccine efficacy against SARS-CoV-2.

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Fear, Affective Semiosis, and Management of the Pandemic Crisis: Covid-19 as Semiotic Vaccine?

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