Dataset Information
Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling.
Ontology highlight
ABSTRACT:
SUBMITTER: Butner JD
PROVIDER: S-EPMC8629426 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling.
eLife 20211109
<h4>Background</h4>Checkpoint inhibitor therapy of cancer has led to markedly improved survival of a subset of patients in multiple solid malignant tumor types, yet the factors driving these clinical responses or lack thereof are not known. We have developed a mechanistic mathematical model for better understanding these factors and their relations in order to predict treatment outcome and optimize personal treatment strategies.<h4>Methods</h4>Here, we present a translational mathematical model ...[more]