Ontology highlight
ABSTRACT:
SUBMITTER: Ogushi S
PROVIDER: S-EPMC8629431 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Ogushi Sugako S Rattani Ahmed A Godwin Jonathan J Metson Jean J Schermelleh Lothar L Nasmyth Kim K
Developmental cell 20211109 22
Protection of peri-centromeric (periCEN) REC8 cohesin from Separase and sister kinetochore (KT) attachment to microtubules emanating from the same spindle pole (co-orientation) ensures that sister chromatids remain associated after meiosis I. Both features are lost during meiosis II, resulting in sister chromatid disjunction and the production of haploid gametes. By transferring spindle-chromosome complexes (SCCs) between meiosis I and II in mouse oocytes, we discovered that both sister KT co-or ...[more]