Ontology highlight
ABSTRACT:
SUBMITTER: Uxa S
PROVIDER: S-EPMC8629999 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Uxa Sigrid S Castillo-Binder Paola P Kohler Robin R Stangner Konstanze K Müller Gerd A GA Engeland Kurt K
Cell death and differentiation 20210628 12
Ki-67 serves as a prominent cancer marker. We describe how expression of the MKI67 gene coding for Ki-67 is controlled during the cell cycle. MKI67 mRNA and Ki-67 protein are maximally expressed in G<sub>2</sub> phase and mitosis. Expression is dependent on two CHR elements and one CDE site in the MKI67 promoter. DREAM transcriptional repressor complexes bind to both CHR sites and downregulate the expression in G<sub>0</sub>/G<sub>1</sub> cells. Upregulation of MKI67 transcription coincides with ...[more]