Ontology highlight
ABSTRACT:
SUBMITTER: Nandanan KG
PROVIDER: S-EPMC8633088 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Nandanan Krishnaprasad G KG Salim Sagar S Pankajam Ajith V AV Shinohara Miki M Lin Gen G Chakraborty Parijat P Farnaz Amamah A Steinmetz Lars M LM Shinohara Akira A Nishant Koodali T KT
Genetics 20211001 2
In the baker's yeast Saccharomyces cerevisiae, most of the meiotic crossovers are generated through a pathway involving the highly conserved mismatch repair related Msh4-Msh5 complex. To understand the role of Msh4-Msh5 in meiotic crossing over, we determined its genome wide in vivo binding sites in meiotic cells. We show that Msh5 specifically associates with DSB hotspots, chromosome axes, and centromeres on chromosomes. A basal level of Msh5 association with these chromosomal features is obser ...[more]