Discrimination Between Primary Lung Cancer and Lung Metastases by Genomic Profiling.

ABSTRACT:

Introduction

In cases of lung tumors that occur after treatment for malignancies in other organs, the tumor may represent either a primary lung cancer or a solitary pulmonary metastasis from the other tumor. Because some lung tumors are difficult to differentiate on the basis of imaging and pathologic findings, treatment selection is often difficult. In this study, we attempted to make a genomic diagnosis of primary and metastatic lung tumors by analyzing tumor samples using next-generation sequencing and evaluated the efficacy and validity of the genomic diagnosis.

Methods

A total of 24 patients with a solitary lung nodule and a history of other malignancies were enrolled in this study. Tumor cells were selected from tissue samples using laser capture microdissection. DNA w

SUBMITTER: Higuchi R 

PROVIDER: S-EPMC8633675 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature