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One-year follow-up of treatment outcomes and patient opinions of Retraining and Control Therapy (ReACT) for pediatric functional seizures.

ABSTRACT: Retraining and Control Therapy (ReACT), a short-term treatment for pediatric functional seizures (FS), has been demonstrated to improve FS in children compared to supportive therapy. However, long-term maintenance of FS-reduction after ReACT is unclear. This study aims to assess seizure frequency 1 year after ReACT and determine patient and parents' opinions of ReACT. Children with functional seizures who previously completed ReACT and their parents were asked to report 30-day FS frequency 1 year after completing ReACT. They also reported if ReACT was helpful. Paired samples t-tests were used to compare FS frequency before ReACT to 1 year after and to compare FS frequency in 30 days after ReACT to 1 year after. Fourteen children (Mean_age = 15.43) and their parents participated. Seven-day FS frequency for patients at 1-year follow-up (Mean = 0.15) was significantly lower than 7-day FS frequency pre-ReACT (Mean = 5.62; p = 0.005). No differences were found when comparing FS frequency during 30 days post-ReACT (Mean = 0.29) and in 30 days before 1-year follow-up (Mean = 0.71). This study confirms long-term maintenance of FS-reduction after ReACT and supports the efficacy of targeting FS directly as opposed to mood or stress for reducing FS. Additionally, children and parents believe ReACT is beneficial.

SUBMITTER: Stager L

PROVIDER: S-EPMC8633863 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundIn this study, we tested the efficacy of a low-intensity lifestyle intervention aimed at reducing the risk of cardiovascular disease among mid-life individuals.MethodsWe conducted a randomized controlled trial in which participants were randomly assigned either to receive a health report card with counselling (from a Telehealth nurse) on smoking, exercise, nutrition and stress or to receive usual care. The patients were divided into 2 groups on the basis of risk: the primary prevention group, with a Framingham risk score of 10% or higher (intervention, n = 157; control, n = 158), and the secondary prevention group, who had a diagnosis of coronary artery disease (intervention, n = 153; control, n = 143). The primary outcome was a change in the Framingham global risk score between baseline and 1-year follow-up. Data were analyzed separately for the 2 prevention groups using an intention-to-treat analysis controlling for covariates.ResultsWithin the primary prevention group, there were statistically significant changes for the treatment group relative to the controls, from baseline to year 1, in Framingham score (intervention, -3.10 [95% confidence interval (CI) -3.98 to -2.22]; control, -1.30 [95% CI -2.18 to -0.42]; p < 0.01) and scores for total cholesterol (intervention, -0.41 [95% CI -0.59 to -0.23]; control, -0.14 [95% CI -0.32 to 0.04]; p < 0.05), systolic blood pressure (intervention, -7.49 [95% CI -9.97 to -5.01]; control, -3.58 [95% CI -6.08 to -1.08]; p < 0.05), nutrition level (intervention, 0.30 [95% CI 0.13 to 0.47]; control, -0.05 [95% CI -0.22 to 0.12]; p < 0.01), and health confidence (intervention, 0.20 [95% CI 0.09 to 0.31]; control, 0.04 [95% CI -0.07 to 0.15]; p < 0.05), with adjustment for covariates. No significant changes in outcome variables were found for the secondary prevention group.InterpretationWe found evidence for the efficacy of an intervention addressing multiple risk factors for primary prevention at 1 year using Framingham risk score report cards and telephone counselling. (Requirement for clinical trial registration waived [enrolment completed before requirement became applicable].).

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One-year follow-up of treatment outcomes and patient opinions of Retraining and Control Therapy (ReACT) for pediatric functional seizures.

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