Ontology highlight
ABSTRACT:
SUBMITTER: Datta D
PROVIDER: S-EPMC8634091 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Datta Dibyadeep D Leslie Shannon N SN Woo Elizabeth E Amancharla Nishita N Elmansy Ayah A Lepe Miguel M Mecca Adam P AP Slusher Barbara S BS Nairn Angus C AC Arnsten Amy F T AFT
Frontiers in aging neuroscience 20211115
Glutamate carboxypeptidase II (GCPII) expression in brain is increased by inflammation, and reduces NAAG (N-acetyl aspartyl glutamate) stimulation of mGluR3 signaling. Genetic insults in this signaling cascade are increasingly linked to cognitive disorders in humans, where increased GCPII and or decreased NAAG-mGluR3 are associated with impaired prefrontal cortical (PFC) activation and cognitive impairment. As aging is associated with increased inflammation and PFC cognitive deficits, the curren ...[more]