A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila.
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ABSTRACT:
SUBMITTER: Musso PY
PROVIDER: S-EPMC8635442 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in <i>Drosophila</i>.
Musso Pierre-Yves PY Junca Pierre P Gordon Michael D MD
Science advances 20211201 49
In flies, neuronal sensors detect prandial changes in circulating fructose levels and either sustain or terminate feeding, depending on internal state. Here, we describe a three-part neural circuit that imparts satiety-dependent modulation of fructose sensing. We show that dorsal fan-shaped body neurons display oscillatory calcium activity when hemolymph glucose is high and that these oscillations require glutamatergic input from SLP-AB or “Janus” neurons projecting from the protocerebrum to the ...[more]
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