Ontology highlight
ABSTRACT:
SUBMITTER: Floser A
PROVIDER: S-EPMC8635974 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Flöser Anja A Becker Katharina K Kostenis Evi E König Gabriele G Krasel Cornelius C Kolb Peter P Bünemann Moritz M
eLife 20211201
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses - termed bias - potentially by eliciting different levels of recruitment of effector proteins. As activation and recruitment of effector proteins might influence each other, thorough analysis of bias is difficult. Here, we compared the efficacy of seven agonists to induce G protein, G pr ...[more]