Heterogeneity of non-alcoholic fatty liver disease: Implications for clinical practice and research activity.

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous condition with a wide spectrum of clinical presentations and natural history and disease severity. There is also substantial inter-individual variation and variable response to a different therapy. This heterogeneity of NAFLD is in turn influenced by various factors primarily demographic/dietary factors, metabolic status, gut microbiome, genetic predisposition together with epigenetic factors. The differential impact of these factors over a variable period of time influences the clinical phenotype and natural history. Failure to address heterogeneity partly explains the sub-optimal response to current and emerging therapies for fatty liver disease. Consequently, leading experts across the globe have recently suggested a change in

SUBMITTER: Pal P 

PROVIDER: S-EPMC8637673 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature