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Insight into the Technical Qualification of the Sonocogreen CaO/Clinoptilolite Nanocomposite (CaO_(NP)/Clino) as an Advanced Delivery System for 5-Fluorouracil: Equilibrium and Cytotoxicity.

ABSTRACT: Clinoptilolite as a natural zeolite was integrated with green CaO nanoparticles forming the green nanocomposite CaO_(NP)/Clino. The CaO_(NP)/Clino composite was assessed as a potential carrier for 5-fluorouracil (5-FL) drug. The CaO_(NP)/Clino carrier achieved an enhanced 5-FL loading capacity of 305.3 mg/g as compared to 163 mg/g for pure clinoptilolite. The kinetics of the 5-FL loading follow the properties of the pseudo-first-order model, while the equilibrium results are related to the Langmuir isotherm. Therefore, the 5-FL loading processes occurred in the monolayer formed by homogeneous active loading receptors on the surface of the CaO_(NP)/Clino carrier. The Gaussian energy of the 5-FL loading reaction (9.2 KJ/mol) reflected the dominant effect for the chemical mechanisms, especially the zeolitic ion-exchange mechanisms. Additionally, the thermodynamic parameters suggested endothermic, feasible, and spontaneous properties for the occurred 5-FL loading reactions. The release profile of 5-FL from CaO_(NP)/Clino has continuous and long properties (150 h) at pH 1.2 (gastric fluid) and pH 7.4 (intestinal fluid). The kinetic studies of the release reactions show considerable agreement with Higuchi, Hixson-Crowell, and Korsmeyer-Peppas models. Such high fitting results and the diffusion exponent values (0.49 at pH 1.2 and 0.48 at pH 7.4) reflected the release properties of the Fickian transport behavior involving complex erosion and diffusion mechanisms. The cytotoxicity study of CaO_(NP)/Clino on colorectal normal cells (CCD-18Co) declare the safe and biocompatible effect as a carrier for the 5-FL drug. Additionally, CaO_(NP)/Clino as a carrier causes considerable enhancement for the cytotoxic effect of the loaded 5-FL drug on colon cancer cells (HCT-116).

SUBMITTER: Abukhadra MR

PROVIDER: S-EPMC8637967 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:In this article, the TiO2/SiO2-np nanocomposite multilayer films were synthesized in a single step by reactive magnetron sputtering combined with a nanoparticle aerosol jet. The SiO2 nanoparticles (SiO2-np) were introduced into a growing TiO2 thin film with different time sequences during deposition for a fixed duration. The SiO2-np acting as impurities are introduced into the TiO2 to willingly disturb its growth and to cause growth defects in order to increase the specific surface area of the photocatalytic film. In reason of the non-photoactive properties of the SiO2 nanoparticles, their introduction allows us to study only the effects induced on the film morphology, microstructure, and photocatalytic properties by their incorporation. The fractographies and topographies reveal strong changes in the morphologies depending on the time sequence of the nanoparticle introduction in the thin films. The introduction of SiO2-np from the beginning of the TiO2 film growth leads to the formation of high and large growth defects resulting in a highly diffusive surface. In addition, XRD analysis shows that the crystallite size tends to decrease as the composite film layer gets closer to the surface. Their photocatalytic performance is obtained by following the degradation of orange G dye under UV-visible irradiation. The photocatalytic performance is not only related to the specific surface area of the catalyst film, and the coverage of the photoactive phase on the surface, but also to the crystal quality of the photoactive phase. Furthermore, the samples exhibit good photostability, maintaining the same activity after four degradation cycles. In the specific case of TiO2/SiO2-np, it is demonstrated that the introduction of the nanoparticles only at the beginning of the film growth is more efficient than a continuous introduction. This result suggests that this original process allows the use of a relevant strategy for the nanoparticle introduction according to the required functionality.

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Insight into the Technical Qualification of the Sonocogreen CaO/Clinoptilolite Nanocomposite (CaO_(NP)/Clino) as an Advanced Delivery System for 5-Fluorouracil: Equilibrium and Cytotoxicity.

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Insight into the Technical Qualification of the Sonocogreen CaO/Clinoptilolite Nanocomposite (CaO(NP)/Clino) as an Advanced Delivery System for 5-Fluorouracil: Equilibrium and Cytotoxicity.

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Insight into the Technical Qualification of the Sonocogreen CaO/Clinoptilolite Nanocomposite (CaO_(NP)/Clino) as an Advanced Delivery System for 5-Fluorouracil: Equilibrium and Cytotoxicity.