Ontology highlight
ABSTRACT:
SUBMITTER: Shimoda M
PROVIDER: S-EPMC8639922 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Communications biology 20211202 1
In herpesvirus replicating cells, host cell gene transcription is frequently down-regulated because important transcriptional apparatuses are appropriated by viral transcription factors. Here, we show a small peptide derived from the Kaposi's sarcoma-associated herpesvirus transactivator (K-Rta) sequence, which attenuates cellular MYC expression, reduces cell proliferation, and selectively kills cancer cell lines in both tissue culture and a xenograft tumor mouse model. Mechanistically, the pept ...[more]