Association Between Sex and Immune Checkpoint Inhibitor Outcomes for Patients With Melanoma.

ABSTRACT:

Importance

Immune checkpoint inhibitors (ICIs) have revolutionized melanoma treatment and are now standard of care. Although sex is associated with immune function and immune-related diseases, the interaction between sex and ICIs is understudied.

Objective

To examine whether cancer immunotherapy effectiveness varies between female and male patients with advanced melanoma treated with either nivolumab plus ipilimumab combination therapy or anti-programmed cell death protein 1 (PD-1) therapy (namely, pembrolizumab or nivolumab).

Design, setting, and participants

The study population consisted of 1369 older adults (aged ≥65 years) with a record of melanoma diagnosis from January 1, 1991, to December 31, 2015, in the Surveillance, Epidemiology, and End Results-Medicare li

SUBMITTER: Jang SR 

PROVIDER: S-EPMC8640892 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature