Exploring cell-specific miRNA regulation with single-cell miRNA-mRNA co-sequencing data.

ABSTRACT:

Background

Existing computational methods for studying miRNA regulation are mostly based on bulk miRNA and mRNA expression data. However, bulk data only allows the analysis of miRNA regulation regarding a group of cells, rather than the miRNA regulation unique to individual cells. Recent advance in single-cell miRNA-mRNA co-sequencing technology has opened a way for investigating miRNA regulation at single-cell level. However, as currently single-cell miRNA-mRNA co-sequencing data is just emerging and only available at small-scale, there is a strong need of novel methods to exploit existing single-cell data for the study of cell-specific miRNA regulation.

Results

In this work, we propose a new method, CSmiR (Cell-Specific miRNA regulation) to combine single-cell miRNA-mRNA c

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8641245 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature