Hippo signaling suppresses tumor cell metastasis via a Yki-Src42A positive feedback loop.
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ABSTRACT:
SUBMITTER: Ding Y
PROVIDER: S-EPMC8642408 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Hippo signaling suppresses tumor cell metastasis via a Yki-Src42A positive feedback loop.
Ding Yan Y Wang Guiping G Zhan Meixiao M Sun Xiaohan X Deng Yanran Y Zhao Yunhe Y Liu Bin B Liu Qingxin Q Wu Shian S Zhou Zizhang Z
Cell death & disease 20211203 12
Metastasis is an important cause of death from malignant tumors. It is of great significance to explore the molecular mechanism of metastasis for the development of anti-cancer drugs. Here, we find that the Hippo pathway hampers tumor cell metastasis in vivo. Silence of hpo or its downstream wts promotes tumor cell migration in a Yki-dependent manner. Furthermore, we identify that inhibition of the Hippo pathway promotes tumor cell migration through transcriptional activating src42A, a Drosophil ...[more]
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