Dataset Information

Pharmacological insights into autophagy modulation in autoimmune diseases.

ABSTRACT: As a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse biological processes. Genome-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), indicating that autophagy dysregulation may be involved in the development of autoimmune diseases. A series of autophagy modulators have displayed protective effects on autoimmune disease models, highlighting the emerging role of autophagy modulators in treating autoimmune diseases. This review explores the roles of autophagy in the autoimmune diseases, with emphasis on four major autoimmune diseases [SLE, rheumatoid arthritis (RA), IBD, and experimental autoimmune encephalomyelitis (EAE)]. More importantly, the therapeutic potentials of small molecular autophagy modulators (including autophagy inducers and inhibitors) on autoimmune diseases are comprehensively analyzed.

SUBMITTER: Wu MY

PROVIDER: S-EPMC8642426 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Pharmacological insights into autophagy modulation in autoimmune diseases.

Wu Ming-Yue MY Wang Er-Jin EJ Feng Du D Li Min M Ye Richard D RD Lu Jia-Hong JH

Acta pharmaceutica Sinica. B 20210322 11

As a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse biological processes. Genome-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), indicating that autophagy dysregulation may be involved in the development of autoimmune diseases. A series of autophagy modulators have displayed protective effects on au ...[more]

PMID: 34900523

Similar Datasets

Project description:BackgroundMogamulizumab is a monoclonal antibody targeting the C-C chemokine receptor 4, used to treat T-cell malignancies such as cutaneous T-cell lymphoma, adult T-cell leukemia/lymphoma, and peripheral T-cell lymphoma. However, real-world studies on mogamulizumab-associated adverse events (AEs) are limited.MethodsDisproportionality analyses were performed to assess the safety profile of mogamulizumab based on data from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database for the period spanning from October 2018 to December 2023. The research investigated demographic characteristics, the onset timing of AEs, and the safety implications associated with mogamulizumab use.ResultsA total of 1182 significant preferred terms were identified among the 3661 mogamulizumab-associated AE reports collected from the FAERS database. The frequently reported AEs including rash, infusion-related reaction, and pyrexia were in line with drug instruction. Notably, several unexpectedly significant AEs were also found, including pemphigoid (ROR = 5.69 [95% CI 1.83-17.66]), unstable angina (ROR = 20.56 [95% CI 8.54-49.5]), bulbar palsy (ROR = 238.36 [95% CI 75.22-755.31]), myositis (ROR = 12.65 [95% CI 5.67-28.19]), and various autoimmune diseases such as autoimmune hepatitis (ROR = 21.33 [95% CI 11.08-41.07]), myocarditis (ROR = 15.29 [95% CI 8.67-26.97]), glomerulonephritis (ROR = 22.49 [95% CI 7.24-69.9]), nephrotic syndrome (ROR = 7.63 [95% CI 2.46-23.67]), myasthenia gravis (ROR = 8.54 [95% CI 3.2-22.77]), and autoimmune thyroiditis (ROR = 11.81 [95% CI 3.8-36.68]).ConclusionThis study replicated previously identified AEs associated with mogamulizumab and uncovered additional signals of AEs, particularly emphasizing the risks associated with autoimmune diseases. It is essential to exercise vigilance in monitoring the occurrence of these AEs during the use of mogamulizumab in clinical practice.

Dataset Information

Pharmacological insights into autophagy modulation in autoimmune diseases.

Publications

Pharmacological insights into autophagy modulation in autoimmune diseases.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets