Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy.
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ABSTRACT:
SUBMITTER: Hofmaier J
PROVIDER: S-EPMC8645917 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy.
Hofmaier Jan J Walter Franziska F Hadi Indrawati I Rottler Maya M von Bestenbostel Rieke R Dedes George G Parodi Katia K Niyazi Maximilian M Belka Claus C Kamp Florian F
Physics and imaging in radiation oncology 20211001
Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range uncertainty in a variance-based sensitivity analysis (SA). For ten patients with skull base meningioma, the mean calculation time to perform the SA including 1.6 × 10<sup>4</sup> dose recalculations was 5 ...[more]
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