Dataset Information

Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021.

ABSTRACT: We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was presumably stimulated by the widespread reopening after COVID-19 lockdown. Most cases were identified in September, but more are to be expected in the coming months. Reinforcement of clinical awareness, diagnostic capacities and surveillance of EV-D68 is urgently needed in Europe.

SUBMITTER: Benschop KS

PROVIDER: S-EPMC8646978 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021.

Benschop Kimberley Sm KS Albert Jan J Anton Andres A Andrés Cristina C Aranzamendi Maitane M Armannsdóttir Brynja B Bailly Jean-Luc JL Baldanti Fausto F Baldvinsdóttir Guðrún Erna GE Beard Stuart S Berginc Natasa N Böttcher Sindy S Blomqvist Soile S Bubba Laura L Calvo Cristina C Cabrerizo Maria M Cavallero Annalisa A Celma Cristina C Ceriotti Ferruccio F Costa Inês I Cottrell Simon S Del Cuerpo Margarita M Dean Jonathan J Dembinski Jennifer L JL Diedrich Sabine S Diez-Domingo Javier J Dorenberg DagnyHaug D Duizer Erwin E Dyrdak Robert R Fanti Diana D Farkas Agnes A Feeney Susan S Flipse Jacky J De Gascun Cillian C Galli Cristina C Georgieva Irina I Gifford Laura L Guiomar Raquel R Hönemann Mario M Ikonen Niina N Jeannoël Marion M Josset Laurence L Keeren Kathrin K López-Labrador F Xavier FX Maier Melanie M McKenna James J Meijer Adam A Mengual-Chuliá Beatriz B Midgley Sofie E SE Mirand Audrey A Montes Milagrosa M Moore Catherine C Morley Ursula U Murk Jean-Luc JL Nikolaeva-Glomb Lubomira L Numanovic Sanela S Oggioni Massimo M Palminha Paula P Pariani Elena E Pellegrinelli Laura L Piralla Antonio A Pietsch Corinna C Piñeiro Luis L Rabella Núria N Rainetova Petra P Uceda Renteria Sara Colonia SC Romero María P MP Reynders Marijke M Roorda Lieuwe L Savolainen-Kopra Carita C Schuffenecker Isabelle I Soynova Aysa A Swanink Caroline Ma CM Ursic Tina T Verweij Jaco J JJ Vila Jorgina J Vuorinen Tytti T Simmonds Peter P Fischer Thea K TK Harvala Heli H

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20211101 45

We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was presumably stimulated by the widespread reopening after COVID-19 lockdown. Most cases were identified in September, but more are to be expected in the coming months. Reinforcement of clinical awareness, diagnostic capacities and surveillance of EV-D68 is urgently needed in Europ ...[more]

PMID: 34763750

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Project description:BackgroundEnterovirus D68 (EV-D68) is a re-emerging pathogen that is particularly common in children and may cause asthma-like respiratory infection and acute flaccid myelitis. However, in Korea, EV-D68 has never been reported thus far. This study aimed to identify EV-D68 from nasopharyngeal aspirates (NPAs) in Korean children with a respiratory tract infection.Materials and methodsThe EV-D68 reference strain was purchased and blindly used to assess the detection ability of three commercial and one in-house mRT-PCR kit in 2018. Then, we selected children whose specimens were positive for human rhinovirus (HRV) and/or enterovirus (EV) by Allplex mRT-PCR (Seegene, Inc., Seoul, Korea) from April to December 2022. Total RNA was extracted from NPAs, and a partial 5'-UTR gene was amplified and sequenced for the identification of HRV/EV species. Additionally, PCR targeting the VP1 gene was performed to assess EV-D68-positive NPAs, followed by sequencing. Phylogenetic analysis and comparison of amino acid sequence alignments were performed using a partial VP1 gene of our and recent international EV-D68 strains.ResultsAmong the mRT-PCR kits tested, only the in-house kit was able to detect EV-D68 in 2018. However, we detected three EV-D68 strains among children hospitalized with fever and/or respiratory symptoms in September - December 2022 who tested positive for EV by the Allplex kit. Two of them were healthy toddlers with lower respiratory infections accompanied by new-onset wheezing but no neurologic complications. Among 34 children with lower respiratory infection who tested positive for HRV during the same period, EV-D68 was not detected. Phylogenetic analysis revealed that the first Korean EV-D68 belonged to subclade B3. Amino acid sequence alignment of international subclade B3 EV-D68 strains also showed that our strain is genetically more related to those from Europe than those from Japan.ConclusionWe first detected EV-D68 in three Korean children who had EV detected by the Allplex mRT-PCR kit in 2022. EV-D68 also circulated in Korea in fall 2022, but the prevalence and severity seemed to be lower than those in previous reports from other countries.

Dataset Information

Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021.

Publications

Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021.

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