Ontology highlight
ABSTRACT:
SUBMITTER: El Kharraz S
PROVIDER: S-EPMC8647150 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
El Kharraz Sarah S Dubois Vanessa V van Royen Martin E ME Houtsmuller Adriaan B AB Pavlova Ekatarina E Atanassova Nina N Nguyen Tien T Nguyen Tien T Voet Arnout A Eerlings Roy R Handle Florian F Prekovic Stefan S Smeets Elien E Moris Lisa L Devlies Wout W Ohlsson Claes C Poutanen Matti M Verstrepen Kevin J KJ Carmeliet Geert G Launonen Kaisa-Mari KM Helminen Laura L Palvimo Jorma J JJ Libert Claude C Vanderschueren Dirk D Helsen Christine C Claessens Frank F
EMBO reports 20211018 12
Whereas dimerization of the DNA-binding domain of the androgen receptor (AR) plays an evident role in recognizing bipartite response elements, the contribution of the dimerization of the ligand-binding domain (LBD) to the correct functioning of the AR remains unclear. Here, we describe a mouse model with disrupted dimerization of the AR LBD (AR<sup>Lmon/Y</sup> ). The disruptive effect of the mutation is demonstrated by the feminized phenotype, absence of male accessory sex glands, and strongly ...[more]