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Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel.


ABSTRACT: The Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. The Panel reviewed the field literature. As most consistent findings, AD patients with mild cognitive impairment and dementia showed abnormalities in peak frequency, power, and "interrelatedness" at posterior alpha (8-12 Hz) and widespread delta (< 4 Hz) and theta (4-8 Hz) rhythms in relation to disease progression and interventions. The following consensus statements were subscribed: (1) Standardization of instructions to patients, resting state EEG (rsEEG) recording methods, and selection of artifact-free rsEEG periods are needed; (2) power density and "interrelatedness" rsEEG measures (e.g., directed transfer function, phase lag index, linear lagged connectivity, etc.) at delta, theta, and alpha frequency bands may be use for stratification of AD patients and monitoring of disease progression and intervention; and (3) international multisectoral initiatives are mandatory for regulatory purposes.

SUBMITTER: Babiloni C 

PROVIDER: S-EPMC8647863 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel.

Babiloni Claudio C   Arakaki Xianghong X   Azami Hamed H   Bennys Karim K   Blinowska Katarzyna K   Bonanni Laura L   Bujan Ana A   Carrillo Maria C MC   Cichocki Andrzej A   de Frutos-Lucas Jaisalmer J   Del Percio Claudio C   Dubois Bruno B   Edelmayer Rebecca R   Egan Gary G   Epelbaum Stephane S   Escudero Javier J   Evans Alan A   Farina Francesca F   Fargo Keith K   Fernández Alberto A   Ferri Raffaele R   Frisoni Giovanni G   Hampel Harald H   Harrington Michael G MG   Jelic Vesna V   Jeong Jaeseung J   Jiang Yang Y   Kaminski Maciej M   Kavcic Voyko V   Kilborn Kerry K   Kumar Sanjeev S   Lam Alice A   Lim Lew L   Lizio Roberta R   Lopez David D   Lopez Susanna S   Lucey Brendan B   Maestú Fernando F   McGeown William J WJ   McKeith Ian I   Moretti Davide Vito DV   Nobili Flavio F   Noce Giuseppe G   Olichney John J   Onofrj Marco M   Osorio Ricardo R   Parra-Rodriguez Mario M   Rajji Tarek T   Ritter Petra P   Soricelli Andrea A   Stocchi Fabrizio F   Tarnanas Ioannis I   Taylor John Paul JP   Teipel Stefan S   Tucci Federico F   Valdes-Sosa Mitchell M   Valdes-Sosa Pedro P   Weiergräber Marco M   Yener Gorsev G   Guntekin Bahar B  

Alzheimer's & dementia : the journal of the Alzheimer's Association 20210415 9


The Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. The Panel reviewed the field literature. As most consistent findings, AD patients with mild cognitive impairment and dementia showed abnormalities in peak frequency, power, and "interrelatedness" at posterior alpha (8-12 Hz) and widespread delta (< 4 Hz) and theta (4-8 Hz) rhythms in relation  ...[more]

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