Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway.

ABSTRACT:

Purpose

Cancer stem cells represent a cancer cell subpopulation that has been found to be associated with metastasis and chemoresistance. Therefore, it is vital to identify mechanisms regulating cancer stemness. Previously, we have shown that the atypical cyclin P (CCNP), also known as CNTD2, is upregulated in lung and colorectal cancers and is associated with a worse clinical prognosis. Given that other cyclins have been implicated in pluripotency regulation, we hypothesized that CCNP may also play a role in cancer stemness.

Methods

Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells (iPSCs) were used to investigate the role of CCNP in stemness. The effects of CCNP on cancer cell stemness and the expression of pluripotency ma

SUBMITTER: Sanchez-Botet A 

PROVIDER: S-EPMC8648692 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature