Ontology highlight
ABSTRACT:
SUBMITTER: Farha S
PROVIDER: S-EPMC8649443 | biostudies-literature | 2021 Oct-Dec
REPOSITORIES: biostudies-literature
Farha Samar S Comhair Suzy S Hou Yuan Y Park Margaret M MM Sharp Jacqueline J Peterson Laura L Willard Belinda B Zhang Renliang R DiFilippo Frank P FP Neumann Donald D Tang W H Wilson WHW Cheng Feixiong F Erzurum Serpil S
Pulmonary circulation 20211001 4
Alterations in metabolism and bioenergetics are hypothesized in the mechanisms leading to pulmonary vascular remodeling and heart failure in pulmonary hypertension (PH). To test this, we performed metabolomic analyses on 30 PH individuals and 12 controls. Furthermore, using 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography, we dichotomized PH patients into metabolic phenotypes of high and low right ventricle (RV) glucose uptake and followed them longitudinally. In support of metabolic ...[more]