Project description:Allergic and irritant contact dermatitis induces different immunological cascades, involving a plethora of immune cells as well as keratinocytes. This highly interwoven network is regulated by miRNAs. However, which miRNAs are involved during allergic- and irritant-induced contact dermatitis is not well investigated. Therefore, we analyzed miRNA and mRNA expression data of the same sample from positive patch test reactions from 27 patients topically exposed to allergens (nickel (Ni), epoxy resin (EP) and methylchloroisothiazolinone (CM); each n=5), irritants (sodium lauryl sulfate (SL, n=9) and nonanoic acid (NO, n=5)), as well as healthy skin (n=5).

2020-07-01 | E-MTAB-9026 | biostudies-arrayexpress

Integrative analysis of miRNA/mRNA expression patterns in allergic contact dermatitis

2020-07-01 | E-MTAB-9051 | biostudies-arrayexpress

NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify.

Project description: Not available

| S-EPMC7560080 | biostudies-literature

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.

Project description: Not available

| S-EPMC3752543 | biostudies-literature

Electrophilic nitro-fatty acids suppress allergic contact dermatitis in mice.

Project description: Not available

| S-EPMC5352476 | biostudies-literature

Immune Response in Allergic Contact Dermatitis: An Integrated Learning Module.

Project description: Not available

| S-EPMC6342427 | biostudies-literature

Molecular analysis in SADBE-induced ACD (Allergic contact dermatitis) model

Project description:The mechanisms underlying pruritus of SADBE induced ACD (Allergic contact dermatitis) remain poorly understood,due to limited clinical data and animal studies. In this study, we investigated whether there are certain key signaling molecules downstream of the recently identified peptides mediating itch in the spinal cord. We investigated the changes in the trascriptome by performing RNAseq of cervical spinal cords in control and SADBE induced ACD model. Our study represents the detailed analysis of transcriptomes of spinal cord in chronic itch model with biologic replicates, generated by RNA-seq technology.

2023-06-16 | GSE152646 | GEO

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