Stalling interkinetic nuclear migration in curved pseudostratified epithelium of developing cochlea.

ABSTRACT: The bending of epithelial tubes is a fundamental process in organ morphogenesis, driven by various multicellular behaviours. The cochlea in the mammalian inner ear is a representative example of spiral tissue architecture where the continuous bending of the duct is a fundamental component of its morphogenetic process. Although the cochlear duct morphogenesis has been studied by genetic approaches extensively, it is still unclear how the cochlear duct morphology is physically formed. Here, we report that nuclear behaviour changes are associated with the curvature of the pseudostratified epithelium during murine cochlear development. Two-photon live-cell imaging reveals that the nuclei shuttle between the luminal and basal edges of the cell is in phase with cell-cycle progression, known as i

SUBMITTER: Ishii M 

PROVIDER: S-EPMC8652271 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature