Misleading Reporting (Spin) in Noninferiority Randomized Clinical Trials in Oncology With Statistically Not Significant Results: A Systematic Review.

ABSTRACT:

Importance

Spin, the inaccurate reporting of randomized clinical trials (RCTs) with results that are not statistically significant for the primary end point, distorts interpretation of results and leads to misinterpretation. However, the prevalence of spin and related factors in noninferiority cancer RCTs remains unclear.

Objective

To examine misleading reporting, or spin, and the associated factors in noninferiority cancer RCTs through a systematic review.

Data sources

A systematic search of the PubMed database was performed for articles published between January 1, 2010, and December 31, 2019, using the Cochrane Highly Sensitive Search Strategy.

Study selection

Two investigators independently selected studies using the inclusion criteria of noninferiority par

SUBMITTER: Ito C 

PROVIDER: S-EPMC8652604 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature