Human Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices.

ABSTRACT: Complement activation is key to anti-microbial defenses by directly acting on microbes and indirectly by triggering cellular immune responses. Complement activation may also contribute to the pathogenesis of numerous inflammatory and immunological diseases. Consequently, intense research focuses on developing therapeutics that block pathology-causing complement activation while preserving anti-microbial complement activities. However, the pace of research is slowed down significantly by the limitations of current tools for evaluating complement-targeting therapeutics. Moreover, the effects of potential therapeutic agents on innate immune cells, like neutrophils, are not fully understood. Here, we employ microfluidic assays and measure chemotaxis, phagocytosis, and swarming changes in human

SUBMITTER: Muldur S 

PROVIDER: S-EPMC8653703 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature