Ontology highlight
ABSTRACT:
SUBMITTER: Sulskis D
PROVIDER: S-EPMC8654288 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Šulskis Darius D Thoma Johannes J Burmann Björn M BM
Science advances 20211208 50
Protein quality control is an essential cellular function mainly executed by a vast array of different proteases and molecular chaperones. One of the bacterial high temperature requirement A (HtrA) protein family members, the homo-oligomeric DegP protease, plays a crucial role in the <i>Escherichia coli</i> protein quality control machinery by removing unfolded proteins or preventing their aggregation and chaperoning them to their final folded state within the periplasm. DegP contains two regula ...[more]