Unknown

Dataset Information

0

Sex-Specific Microglial Activation and SARS-CoV-2 Receptor Expression Induced by Chronic Unpredictable Stress.


ABSTRACT: The coronavirus disease 2019 (COVID-19) pandemic has generated a lot of stress and anxiety among not only infected patients but also the general population across the globe, which disturbs cerebral immune homeostasis and potentially exacerbates the SARS-CoV-2 virus-induced neuroinflammation, especially among people susceptible to neuropsychiatric disorders. Here, we used a chronic unpredictable mild stress (CUMS) mouse model to study its effects on glia-mediated neuroinflammation and expression of SARS-CoV2 viral receptors. We observed that female mice showed depressive-like behavior after CUMS, whereas male mice showed enhanced anxiety and social withdrawal. Interestingly, CUMS led to increased amounts of total and MHCII+ microglia in the hippocampi of female mice but not male mice. mRNA levels of SARS-CoV-2 viral receptors angiotensin-converting enzyme 2 (Ace2) and basigin (Bsg) were also upregulated in the prefrontal cortices of stressed female mice but not male mice. Similarly, sex-specific changes in SARS-CoV-2 viral receptors FURIN and neuropilin-1 (NRP1) were also observed in monocytes of human caregivers enduring chronic stress. Our findings provided evidence on detrimental effects of chronic stress on the brain and behavior and implied potential sex-dependent susceptibility to SARS-CoV-2 infection after chronic stress.

SUBMITTER: Yan L 

PROVIDER: S-EPMC8654352 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7177572 | biostudies-literature
| S-EPMC10023455 | biostudies-literature
| S-EPMC6585390 | biostudies-literature
| S-EPMC9843707 | biostudies-literature
| S-EPMC8217647 | biostudies-literature
| S-EPMC6430618 | biostudies-literature
| S-EPMC7961142 | biostudies-literature
| S-EPMC6035866 | biostudies-literature
| S-EPMC7686052 | biostudies-literature
| S-EPMC10303162 | biostudies-literature